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Review: Angiotensin Peptides and their Pleiotropic Actions

Laboratory for Experimental and Applied Physiology, Romanian Academy, Iasi Branch, Iasi, Romania

Walther Bild

Laboratory for Experimental and Applied Physiology, Romanian Academy, Iasi Branch, Iasi, Romania, wbild{at}umfiasi.ro

Dragomir N Serban

Laboratory for Experimental and Applied Physiology, Romanian Academy, Iasi Branch, Iasi, Romania

The concept of tissue renin-angiotensin systems (RAS) is now well established and it is now usual to think in terms of renal and tissue systems. At the same time it has emerged that angiotensin II (Ang II) is not the only biologically active peptide generated by the RAS. At least three others have been identified: the heptapeptide Ang III, the hexapeptide Ang IV and Ang 1-7. Specific receptors exits for the last two peptides. In addition, the range of possible physiological and pathophysiological properties for Ang II" has been expanding. The current perception of the RAS is therefore that of a much more complex system than previously believed, with autocrine, paracrine and endocrine properties extending beyond the cardiovascular system. This mini-review focuses on the synthetic pathways of the Ang peptides and describes some of their pleiotropic actions.

Key Words: Renin-angiotensin system • Angiotensin II • Angiotensin peptides • Angiotensin receptors

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 6, No. 3, 121-131 (2005)
DOI: 10.3317/jraas.2005.018


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Haulica, I. Articles by Serban, D. N Search for Related Content PubMed PubMed Citation Articles by Haulica, I. Articles by Serban, D. N Social Bookmarking                         What's this?