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Journal of Renin-Angiotensin-Aldosterone System
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Spotlight on Renin

Renin, Prorenin and the Putative (Pro)renin Receptor

AH Jan Danser

Department of Internal Medicine, UMCN St. Radboud, Nijmegen, The Netherlands

Jaap Deinum

Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands

References

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  • Danser AHJ, Derkx FHM, Schalekamp Madh, Hense HW, Riegger GAJ, Schunkert H. Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans. J Hypertens 1998;16:853-62.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Danser AHJ, Deinum J. Renin, Prorenin and the Putative (Pro)renin Receptor. Hypertens 2005;46:1069-76.[Free Full Text]
  • Lenz T., Sealey JE, Maack T. et al. Half-life, hemodynamic, renal, and hormonal effects of prorenin in cynomolgus monkeys. Am J Physiol 1991;260:R804-R810.[Web of Science][Medline] [Order article via Infotrieve]
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  • Deinum J., Derkx FHM, Schalekamp Madh. Probing epitopes on human prorenin during its proteolytic and non-proteolytic activation. Biochim Biophys Acta 1998; 1388:386-96.[CrossRef][Medline] [Order article via Infotrieve]
  • Galen FX, Devaux C., Atlas S. et al. New monoclonal antibodies directed against human renin. Powerful tools for the investigation of the renin system. J Clin Invest 1984; 74:723-35.[Web of Science][Medline] [Order article via Infotrieve]
  • Deinum J., Derkx FHM, Schalekamp Madh. Improved immunoradiometric assay for plasma renin. Clin Chem 1999;45:847-54.[Abstract/Free Full Text]
  • de Bruin RA, Bouhuizen A., Diederich S., Perschel FH, Boomsma F., Deinum J. Validation of a new automated renin assay. Clin Chem 2004;50:2111-16.[Abstract/Free Full Text]
  • van Kats JP, Danser AHJ, van Meegen JR, Sassen LM, Verdouw PD, Schalekamp Madh. Angiotensin production by the heart: a quantitative study in pigs with the use of radiolabeled angiotensin infusions. Circulation 1998;98: 73-81.[Abstract/Free Full Text]
  • van Kats JP, Schalekamp Madh, Verdouw PD, Duncker DJ, Danser AHJ. Intrarenal angiotensin II: interstitial and cellular levels and site of production. Kidney Int 2001;60: 2311-17.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Danser AHJ, van Kats JP, Admiraal PJJ et al. Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis. Hypertension 1994;24:37-48.[Abstract/Free Full Text]
  • Katz SA, Opsahl JA, Lunzer MM, Forbis LM, Hirsch AT Effect of bilateral nephrectomy on active renin, angiotensinogen, and renin glycoforms in plasma and myocardium. Hypertension 1997;30:259-66.[Abstract/Free Full Text]
  • Hilgers KF, Veelken R., Müller DN et al. Renin uptake by the endothelium mediates vascular angiotensin formation. Hypertension 2001;38:243-8.[Abstract/Free Full Text]
  • Kantachuvesiri S., Fleming S., Peters J. et al. Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease. J Biol Chem 2001;276:3672-733.
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  • van den Eijnden Mmed, de Bruin RJA, de Wit E. et al. Transendothelial transport of renin-angiotensin system components. J Hypertens 2002;20:2029-37.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Campbell DJ, Valentijn AJ Identification of vascular renin-binding proteins by chemical cross-linking: inhibition of binding of renin by renin inhibitors. J Hypertens 1994;12: 879-90.[Web of Science][Medline] [Order article via Infotrieve]
  • Müller DN, Fischli W., Clozel JP et al. Local angiotensin II generation in the rat heart: role of renin uptake. Circ Res 1998;82:13-20.[Abstract/Free Full Text]
  • Loudon M., Bing RF, Thurston H., Swales JD Arterial wall uptake of renal renin and blood pressure control. Hypertension 1983;5:629-34.[Abstract/Free Full Text]
  • van Kesteren CAM, Danser AHJ, Derkx FHM et al. Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells. Hypertension 1997;30:1389-96.[Abstract/Free Full Text]
  • Nguyen G., Delarue F., Burcklé C., Bouzhir L., Giller T., Sraer J.-D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002;109:1417-27.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • van den Eijnden Mmed, Saris JJ, de Bruin RJA et al. Prorenin accumulation and activation in human endothelial cells. Importance of mannose 6-phosphate receptors. Arterioscler Thromb Vasc Biol 2001;21:911-16.[Abstract/Free Full Text]
  • Saris JJ, van den Eijnden Mmed, Lamers JMJ, Saxena PR, Schalekamp Madh, Danser AHJ. Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II. Hypertension 2002;39:573-7.[Abstract/Free Full Text]
  • Nguyen G., Delarue F., Berrou J., Rondeau E., Sraer JD Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int 1996;50:1897-903.[Web of Science][Medline] [Order article via Infotrieve]
  • Sealey JE, Catanzaro DF, Lavin TN et al. Specific prorenin/renin binding (ProBP). Identification and characterization of a novel membrane site. Am J Hypertens 1996;9:491-502.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ichihara A., Hayashi M., Kaneshiro Y. et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the `handle` region for nonproteolytic activation of prorenin. J Clin Invest 2004;114:1128-35.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Journal of Renin-Angiotensin-Aldosterone System, Vol. 6, No. 3, 163-165 (2005)
DOI: 10.3317/jraas.2005.025


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This Article
Right arrow Free Full Text (Free PDF) Free
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Right arrow Articles by Danser, A. J.
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