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Journal of Renin-Angiotensin-Aldosterone System
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Role of Angiotensin II in Cardiovascular Disease — Therapeutic Implications of More Than a Century of Research

Carlos M Ferrario

The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA, cferrari{at}wfubmc.edu

More than a century of research on the renin-angiotensin system (RAS) has uncovered the widespread involvement of angiotensin II (Ang II) in the pathophysiology of cardiovascular diseases. A number of outcomes-based mega trials utilising hard clinical endpoints have revealed beneficial effects of angiotensin receptor antagonists (AIIAs/ARBs) in patients with hypertension, heart failure, diabetic nephropathy, and post-myocardial infarction (MI). The results of these studies not only emphasise the importance of Ang II in the pathophysiology of these diseases but have provided the basis for an evidence-based approach for the use of AIIAs in clinical practice. It is hoped that the next 100 years of research into the RAS will uncover hitherto unimaginable therapeutic opportunities.

Key Words: Hypertension • Cardiovascular disease • Diabetes mellitus • Angiotensin II antagonists • ACE inhibitors • Stroke • Heart failure • Post myocardial infarction • Diabetic nephropathy

References

Journal of Renin-Angiotensin-Aldosterone System, Vol. 7, No. 1, 3-14 (2006)
DOI: 10.3317/jraas.2006.003
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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
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Services
Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
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Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ferrario, C. M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferrario, C. M
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