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Introduction
Luis Ruilope
Hospital 12 de Octubre, Madrid, Spain
References
- Primatesta P., Poulter NR Improvement in hypertension management in England: results from the Health Survey for England 2003. J Hypertens 2006;24:1187-92.
- National Institute for Clinical Excellence clinical guideline 34, June 2006. www.nice.org.uk
- Azizi M., Menard J., Bissery A. et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004;15:3126-33.[Abstract/Free Full Text]
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- Wood JM, Maibaum J., Rahuel J. et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 2003;308:698-705.[CrossRef][Web of Science][Medline]
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- Rigel DF, Fu F., Li S. et al. The renin inhibitor aliskiren is a potent and long-acting antihypertensive in double transgenic rats expressing human renin and angiotensinogen genes. J Am Coll Cardiol 2004;43(suppl A):483A. Abstract 1085.
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- Gradman AH, Schmieder RE, Lins RL et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005;111:1012-18.[Abstract/Free Full Text]
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- Uresin Y., Taylor A., Kilo C. et al. Aliskiren, a novel renin inhibitor, has greater BP lowering than ramipril and additional BP lowering when combined with ramipril in patients with diabetes and hypertension. J Hypertens 2006:24(suppl 4):S82 (P4.269).
- Munger MA, Drummond W., Essop MR et al. Aliskiren as add-on to amlodipine provides significant additional blood pressure lowering without increased oedema associated with doubling the amlodipine dose. Abstract presented at WCC/ESC, Barcelona, Spain, 2-6 September, 2006 (P784).
- Sica D., Gradman A., Lederballe O. et al. Aliskiren, a novel renin inhibitor, is well tolerated and has sustained BP-lowering effects alone or in combination with HCTZ during long-term (52 weeks) treatment of hypertension. Abstract presented at WCC/ESC, Barcelona, Spain, 2-6 September, 2006 (P797).
Journal of Renin-Angiotensin-Aldosterone System, Vol. 7, No. 2 suppl,
S1-S2 (2006)
DOI: 10.3317/jraas.2006.031

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