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Interactions between apelin and angiotensin II on rat portal vein

Faculty of Medicine, Department of Physiology, University of Medicine and Pharmacy "Gr. T Popa" Iasi, Romania, bgurzu@ yahoo.com, Faculty of Medicine, Department of Ophthalmology, University of Medicine and Pharmacy "Gr. T Popa" Iasi, Romania

Bogdan Cristian Petrescu

Faculty of Bioengineering, Department of Ophthalmology, University of Medicine and Pharmacy "Gr. T Popa" Iasi, Romania

Marcel Costuleanu

Faculty of Dentistry, Department of General Pathology, University of Medicine and Pharmacy "Gr. T Popa" Iasi, Romania

Gheorghe Petrescu

Faculty of Medicine, Department of Physiology, University of Medicine and Pharmacy "Gr. T Popa" Iasi, Romania, Department of Ophthalmology, University of Medicine and Pharmacy "Gr. T Popa" Iasi, Romania

Apelin (AP), an endogenous ligand of the APJ receptor, is involved in the regulation of cardiovascular homeostasis. Regardless the multiple similarities between AP and angiotensin II (Ang II), their roles seem to be different. We studied both the interactions between Apelin 13 (AP13) and Ang II and to what extent, if any, nitric oxide (NO) is involved.The experiments were performed in endothelium-denuded or endothelium-intact rat portal vein in the presence of 10 µM N(G)-nitro L-arginine methyl ester or 10 µM aminoguanidine. AP13 did not modify the isolated rat portal vein tone by itself, but inhibited the Ang II-induced contractions acting mainly by a NO-dependent mechanism. Our results sustain the hypothesis that AP13 could increase the activity of both constitutive and inducible NO synthase on either endothelium intact or endothelium denuded rat portal vein rings.

Key Words: apelin • angiotensin II • L-NAME • aminoguanidine • isolated rat portal vein

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 7, No. 4, 212-216 (2006)
DOI: 10.3317/jraas.2006.040


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