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The pharmacology of agents that interfere with renin-angiotensin system activity
Domenic A Sica
Division of Nephrology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
References
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- Sica DA Renal handling of angiotensin receptor blockers: clinical relevance. Curr Hypertens Rep 2003;5:337-9.[CrossRef][Web of Science][Medline]
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- Sica DA Angiotensin receptor blockers - new considerations in their mechanism of action. J Clinical Hypertension 2006;8;381-5.[CrossRef]
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- White WB, Lacourciere Y., Davidai G. Effects of the angiotensin II receptor blockers telmisartan versus valsartan on the circadian variation of blood pressure: impact on the early morning period. Am J Hypertens 2004; 17:347-53.[CrossRef][Web of Science][Medline]
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- Sica DA, Gehr TWB, Frishman WH The renin-angiotensin axis: Angiotensin converting enzyme inhibitors and angiotensin-receptor blockers. In: Frishman W, Sonnenblick S, Sica DA (eds.) Cardiovascular Pharmacotherapeutics (2nd edition). New York, NY: McGraw-Hill. 2003: pp. 131-56.
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- Nussberger J., Wuerzner G., Jensen C., Brunner HR Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): comparison with enalapril. Hypertension 2003;39:E1-E8.[CrossRef][Web of Science]
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- Zhao C., Vaidyanathan S., Yeh CM et al. Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus. Clin Pharmacokinet 2006;45:1125-34.[CrossRef][Web of Science][Medline]
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- Vaidyanathan S., Limoges D., Yeh C., Dieterich H. Aliskiren, an orally effective renin inhibitor, shows dose linear pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 2006;79:64(PIII-23).
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- Gradman AH, Schmieder RE, Lins RL et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005;111: 1012-18.[Abstract/Free Full Text]
- Sica D., Gradman A., Lederballe I. et al. Aliskiren, an oral renin inhibitor, provides long-term antihypertensive efficacy and safety in patients with hypertension. Eur Heart J 2006;27(suppl):P797.
- Feldman DL, Persohn E., Schutz H. et al. Renal localization of the renin inhibitor aliskiren. J Clin Hypertens 2006;8 (suppl A):A80.
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Journal of Renin-Angiotensin-Aldosterone System, Vol. 7, No. 4,
247-250 (2006)
DOI: 10.3317/jraas.2006.046

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