SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Renin-Angiotensin-Aldosterone System
This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Zhuo, J. L
Right arrow Articles by Li, X. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhuo, J. L
Right arrow Articles by Li, X. C
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Reviews

Review: Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells

Jia L Zhuo

Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, Michigan 48202, USA, jzhuo1{at}hfhs.org, Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48202, USA

Xiao C Li

Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48202, USA

Angiotensin II (Ang II) has powerful sodium-retaining, growth-promoting and proinflammatory properties in addition to its physiological role in maintaining body salt and fluid balance and blood pressure homeostasis. Increased circulating and local tissue Ang II is one of the most important factors contributing to the development of sodium and fluid retention, hypertension and target organ damage.The importance of Ang II in the pathogenesis of hypertension and target organ injury is best demonstrated by the effectiveness of angiotensin-converting enzyme (ACE) inhibitors and AT1-receptor antagonists in treating hypertension and progressive renal disease including diabetic nephropathy.The detrimental effects of Ang II are mediated primarily by the AT -receptor, while the AT2-receptor may oppose the AT1-receptor. The classical view of the AT1-receptor-mediated effects of Ang II is that the agonist binds its receptors at the cell surface, and following receptor phosphorylation, activates downstream signal transduction pathways and intracellular responses. However, evidence is emerging that binding of Ang II to its cell surface AT1-receptors also activates endocytotic (or internalisation) processes that promote trafficking of both the effector and the receptor into intracellular compartments. Whether internalised Ang II has important intracrine and signalling actions is not well understood.The purpose of this article is to review recent advances in Ang II research with focus on the mechanisms underlying high levels of intracellular Ang II in proximal tubule cells and the contribution of receptor-mediated endocytosis of extracellular Ang II. Further attention is devoted to the question whether intracellular and/or internalised Ang II plays a physiological role by activating cytoplasmic or nuclear receptors in proximal tubule cells.This information may aid future development of drugs to prevent and treat Ang II-induced target organ injury in cardiovascular and renal diseases by blocking intracellular and/or nuclear actions of Ang II.

Key Words: angiotensin II • AT1-receptor signalling • endosomes • kidney • proximal tubule cells • receptor endocytosis

References

  • Tigerstedt R., Bergman PG Kidney and circulation. Scand Arch Physiol 1898;8:223-71.
  • Campbell DJ Circulating and tissue angiotensin systems. J Clin Invest 1987;79:1-6.[Web of Science][Medline] [Order article via Infotrieve]
  • Johnston CI Franz Volhard Lecture. Renin-angiotensin system: a dual tissue and hormonal system for cardiovascular control. J Hypertens Suppl 1992;10:S13-S26.[Medline] [Order article via Infotrieve]
  • Dzau VJ Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension 2001;37:1047-52.[Abstract/Free Full Text]
  • Paul M., Poyan MA, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev 2006;86:747-803.[Abstract/Free Full Text]
  • Lavoie JL, Sigmund CD Minireview: overview of the renin-angiotensin system-an endocrine and paracrine system. Endocrinology 2003;144:2179-83.[Abstract/Free Full Text]
  • Jan Danser AH, Saris JJ Prorenin uptake in the heart: a prerequisite for local angiotensin generation? J Mol Cell Cardiol 2002;34:1463-72.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Nguyen G. Renin/prorenin receptors. Kidney Int 2006;69:1503-06.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Campbell DJ, Valentijn AJ Identification of vascular renin-binding proteins by chemical cross-linking: inhibition of binding of renin by renin inhibitors. J Hypertens 1994;12: 879-90.[Web of Science][Medline] [Order article via Infotrieve]
  • Ihara M., Urata H., Kinoshita A. et al. Increased chymasedependent angiotensin II formation in human atherosclerotic aorta. Hypertension 1999;33:1399-405.[Abstract/Free Full Text]
  • Ferrario CM Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation. Hypertension 2006;47:515-21.[Abstract/Free Full Text]
  • Wright JW, Krebs LT, Stobb JW, Harding JW The angiotensin IV system: functional implications. Front Neuroendocrinol 1995;16:23-52.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Albiston AL, McDowall SG, Matsacos D. et al. Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. J Biol Chem 2001;276:48623-26.[Abstract/Free Full Text]
  • Re RN On the biological actions of intracellular angiotensin. Hypertension 2000;35:1189-90.[Free Full Text]
  • Peters J., Farrenkopf R., Clausmeyer S. et al. Functional significance of prorenin internalization in the rat heart. Circ Res 2002;90:1135-41.[Abstract/Free Full Text]
  • Cook JL, Zhang Z., Re RN In vitro evidence for an intracellular site of angiotensin action. Circ Res 2001;89:1138-46.[Abstract/Free Full Text]
  • De Mello WC, Danser AH Angiotensin II and the heart: on the intracrine renin-angiotensin system. Hypertension 2000;35:1183-8.[Abstract/Free Full Text]
  • Filipeanu CM, Henning RH, Nelemans SA, de Zeeuw D. Intracellular angiotensin II: from myth to reality? JRAAS 2001;2:219-26.[Medline] [Order article via Infotrieve]
  • Lavoie JL, Liu X., Bianco RA, Beltz TG, Johnson AK, Sigmund CD Evidence supporting a functional role for intracellular renin in the brain. Hypertension 2006;47:461-6.[Abstract/Free Full Text]
  • Robertson A., Khairallah P. Angiotensin II: rapid localization in nuclei of smooth and cardiac muscle. Science 1971;172:1138-9.[Abstract/Free Full Text]
  • Re RN Intracellular renin and the nature of intracrine enzymes. Hypertension 2003;42:117-22.[Abstract/Free Full Text]
  • Re RN, Vizard DL, Brown J., LeGros L., Bryan SE Angiotensin II receptors in chromatin. J Hypertens Suppl 1984;2:S271-S273.[Medline] [Order article via Infotrieve]
  • Cook JL, Zhang Z., Re RN Intracellular angiostensin II increases the long isoform of PDGF mRNA in rat hepatoma cells. J Mol Cell Cardiol 2002;34:1525-37.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Cook JL, Mills SJ, Naquin R., Alam J., Re RN Nuclear accumulation of the AT receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation. J Mol Cell Cardiol 2006;40:696-707.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • De Mello WC Intracellular angiotensin II regulates the inward calcium current in cardiac myocytes. Hypertension 1998;32:976-82. current in cardiac myocytes. Hypertension[Abstract/Free Full Text]
  • De Mello WC Renin-angiotensin system and cell communication in the failing heart. Hypertension 1996;27:1267-72.[Abstract/Free Full Text]
  • De Mello WC Renin increments the inward calcium current in the failing heart. J Hypertens 2006;24:1181-6.[Web of Science][Medline] [Order article via Infotrieve]
  • Haller H., Lindschau C., Erdmann B., Quass P., Luft FC Effects of intracellular angiotensin II in vascular smooth muscle cells. Circ Res 1996;79:765-72.[Abstract/Free Full Text]
  • Haller H., Lindschau C., Quass P., Luft FC Intracellular actions of angiotensin II in vascular smooth muscle cells. J Am Soc Nephrol 1999;10(suppl 11):S75-S83.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Danser AH, Deinum J. Renin, proreinin and the putative (pro)renin receptor. Hypertension 2005;46:1069-76.[Free Full Text]
  • Saris JJ, Hoen PA, Garrelds IM et al. Prorenin induces intracellular signalling in cardiomyocytes independently of angiotensin II. Hypertension 2006;48:564-71.[Abstract/Free Full Text]
  • von Thun AM, Vari RC, El Dahr SS, Navar LG Augmentation of intrarenal angiotensin II levels by chronic angiotensin II infusion. Am J Physiol 1994;266:F120-F128.[Web of Science][Medline] [Order article via Infotrieve]
  • Zou LX, Hymel A., Imig JD, Navar LG Renal accumulation of circulating angiotensin II in angiotensin II-infused rats. Hypertension 1996;27:658-62.[Abstract/Free Full Text]
  • van Kats JP, Schalekamp MA, Verdouw PD, Duncker DJ, Danser AH Intrarenal angiotensin II: interstitial and cellular levels and site of production. Kidney Int 2001;60:2311-17.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Johnson RJ, Alpers CE, Yoshimura A. et al. Renal injury from angiotensin II-mediated hypertension. Hypertension 1992;19:464-74.[Abstract/Free Full Text]
  • Zhuo JL, Imig JD, Hammond TG, Orengo S., Benes E., Navar LG Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor. Hypertension 2002;39:116-21.[Abstract/Free Full Text]
  • Douglas JG, Hopfer U. Novel aspect of angiotensin receptors and signal transduction in the kidney. Annu Rev Physiol 1994;56:649-69.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Navar LG, Carmines PK, Huang WC, Mitchell KD The tubular effects of angiotensin II. Kidney Int Suppl 1987;20:S81-S88.[Medline] [Order article via Infotrieve]
  • Harris PJ, Navar LG Tubular transport responses to angiotensin II. Am J Physiol Renal Physiol 1985;248:F621-F630.[Abstract/Free Full Text]
  • Zhuo JL, Allen AM, Alcorn D., MacGregor D., Aldred GP, Mendelsohn FA The distribution of angiotensin II receptors. Laragh, J. H. I and Brenner, B. M. (eds.) Hypertension: Pathology, Diagnosis & Management. 1[2nd Edition], New York: Raven Press, 1995:1739-62.
  • Ruster C., Wolf G. Renin-angiotensin-aldosterone system and progression of renal disease. J Am Soc Nephrol 2006;17:2985-91.[Abstract/Free Full Text]
  • Thomas WG, Thekkumkara TJ, Baker KM Molecular mechanisms of angiotensin II (AT1A) receptor endocytosis. Clin Exp Pharmacol Physiol Suppl 1996;3:S74-S80.[Medline] [Order article via Infotrieve]
  • Ferguson SS Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signalling. Pharmacol Rev 2001;53:1-24.[Abstract/Free Full Text]
  • Gonzalez-Gaitan M. Signal dispersal and transduction through the endocytic pathway. Nat Rev Mol Cell Biol 2003; 4:213-24.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Zhuo JL, Li XC, Garvin JL, Navar LG, Carretero OA Intracellular angiotensin II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells. Am J Physiol Renal Physiol 2006; 290:F1382-F1390.[Abstract/Free Full Text]
  • Li XC, Carretero OA, Navar LG, Zhuo JL AT1a receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases. Am J Physiol Renal Physio 2006;291:F375-F383.[CrossRef]
  • Ruiz-Ortega M., Ruperez M., Lorenzo O. et al. Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney Int Suppl 2002;82:12-22.[Medline] [Order article via Infotrieve]
  • Muller DN, Dechend R., Mervaala EM et al. NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension 2000;35:193-201.[Abstract/Free Full Text]
  • Navar LG, Inscho EW, Majid SA, Imig JD, Harrison Bernard LM, Mitchell KD Paracrine regulation of the renal microcirculation. Physiol Rev 1996;76:425-536.[Abstract/Free Full Text]
  • Mendelsohn FA Angiotensin II: evidence for its role as an intrarenal hormone. Kidney Int Suppl 1982;12:S78-S81.[Medline] [Order article via Infotrieve]
  • Tang SS, Jung F., Diamant D. et al. Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system. Am J Physiol 1995;268:F435-F446.[Web of Science][Medline] [Order article via Infotrieve]
  • Zhuo JL, Mendelsohn FA Intrarenal Angiotensin II Receptors. Robertson JIS and Nicholls MG (eds) The Renin-Angiotensin System: Biochemistry, Pathophysiology and Therapeutics. London & New York, Gower Medical Publishing, 1993:25.1-25.14.
  • Navar LG, Imig JD, Zou L., Wang CT Intrarenal production of angiotensin II. Semin Nephrol 1997;17:412-22.[Web of Science][Medline] [Order article via Infotrieve]
  • Harrison-Bernard LM, Zhuo J., Kobori H., Ohishi M., Navar LG Intrarenal AT(1) receptor and ACE binding in ANG II-induced hypertensive rats. Am J Physiol Renal Physiol 2002;282:F19-F25.[Abstract/Free Full Text]
  • Ingelfinger JR, Jung F., Diamant D. et al. Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback. Am J Physiol 1999;276:F218-F227.[Web of Science][Medline] [Order article via Infotrieve]
  • Tang SS, Jung F., Diamant D. et al. Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system. Am J Physiol 1995;268:F435-F446.[Web of Science][Medline] [Order article via Infotrieve]
  • Douglas JG Angiotensin receptor subtypes of the kidney cortex. Am J Physiol 1987;253:F1-F7.[Web of Science][Medline] [Order article via Infotrieve]
  • Zhuo J., Alcorn D., Harris PJ, Mendelsohn FA Localization and properties of angiotensin II receptors in rat kidney. Kidney Int Suppl 1993;42:S40-S46.[Medline] [Order article via Infotrieve]
  • Dulin NO, Ernsberger P., Suciu DJ, Douglas JG Rabbit renal epithelial angiotensin II receptors. Am J Physiol 1994;267:F776-F782.[Web of Science][Medline] [Order article via Infotrieve]
  • Zhuo J., Song K., Harris PJ, Mendelsohn FA In vitro autoradiography reveals predominantly AT1 angiotensin II receptors in rat kidney. Ren Physiol Biochem 1992;15:231-9.[Web of Science][Medline] [Order article via Infotrieve]
  • de Gasparo M., Catt KJ, Inagami T., Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52:415-72.[Abstract/Free Full Text]
  • Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 1991;351:233-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • MehtaPK, Griendling KK Angiotensin II cell signalling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 2007;292:C82-C97.[Abstract/Free Full Text]
  • Cogan MG Angiotensin II: a powerful controller of sodium transport in the early proximal tubule. Hypertension 1990;15:45-8
  • Zhuo J., Thomas D., Harris PJ, Skinner SL The role of endogenous angiotensin II in the regulation of renal haemodynamics and proximal fluid reabsorption in the rat. J Physiol 1992;453:1-13.[Abstract/Free Full Text]
  • Wolf G., Ziyadeh FN Renal tubular hypertrophy induced by angiotensin II. Semin Nephrol 1997;17:448-54.[Web of Science][Medline] [Order article via Infotrieve]
  • Luft FC Proinflammatory effects of angiotensin II and endothelin: targets for progression of cardiovascular and renal diseases. Curr Opin Nephrol Hypertens 2002;11:59-66.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ruiz-Ortega M., Lorenzo O., Suzuki Y., Ruperez M., Egido J. Proinflammatory actions of angiotensins. Curr Opin Nephrol Hypertens 2001;10:321-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wolf G., Ziyadeh FN, Zahner G., Stahl RA Angiotensin II-stimulated expression of transforming growth factor beta in renal proximal tubular cells: attenuation after stable transfection with the c-mas oncogene. Kidney Int 1995;48:1818-27.[Web of Science][Medline] [Order article via Infotrieve]
  • Touyz RM, Schiffrin EL Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000;52:639-72.[Abstract/Free Full Text]
  • de Gasparo M., Catt KJ, Inagami T., Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52:415-72.[Abstract/Free Full Text]
  • Schelling JR, Singh H., Marzec R., Linas SL Angiotensin II-dependent proximal tubule sodium transport is mediated by cAMP modulation of phospholipase C. Am J Physiol 1994;267:C1239-C1245.[Web of Science][Medline] [Order article via Infotrieve]
  • Thekkumkara TJ, Cookson R., Linas SL Angiotensin (AT1A) receptor-mediated increases in transcellular sodium transport in proximal tubule cells. Am J Physiol 1998;274:F897-F905.[Web of Science][Medline] [Order article via Infotrieve]
  • Carey RM, Wang ZQ, Siragy HM Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function. Hypertension 2000;35:155-63.[Abstract/Free Full Text]
  • Hakam AC, Hussain T. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+- ATPase activity via a NO/cGMP-dependent pathway. Am J Physiol Renal Physiol 2006;290:F1430-F1436.[Abstract/Free Full Text]
  • Siragy HM, Carey RM Angiotensin type 2 receptors: potential importance in the regulation of blood pressure. Curr Opin Nephrol Hypertens 2001;10:99-103.[Web of Science][Medline] [Order article via Infotrieve]
  • De Mello WC Is an intracellular renin-angiotensin system involved in control of cell communication in heart? J Cardiovasc Pharmacol 1994;23:640-6.[Web of Science][Medline] [Order article via Infotrieve]
  • Re R., Parab M. Effect of angiotensin II on RNA synthesis by isolated nuclei. Life Sci 1984;34:647-51.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Navar LG, Lewis L., Hymel A., Braam B., Mitchell KD Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats. J Am Soc Nephrol 1994;5:1153-8.[Abstract]
  • Navar LG, Harrison-Bernard LM, Wang CT, Cervenka L., Mitchell KD Concentrations and actions of intraluminal angiotensin II. J Am Soc Nephrol 1999;10(suppl 11): S189-S195.[Web of Science][Medline] [Order article via Infotrieve]
  • Seikaly MG, Arant BS Jr., Seney FD Jr. Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest 1990;86:1352-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Braam B., Mitchell KD, Fox J., Navar LG Proximal tubular secretion of angiotensin II in rats. Am J Physiol 1993;264:F891-F898.[Web of Science][Medline] [Order article via Infotrieve]
  • Mitchell KD, Jacinto SM, Mullins JJ Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol 1997; 273:F246-F253.[Web of Science][Medline] [Order article via Infotrieve]
  • Siragy HM, Howell NL, Ragsdale NV, Carey RM Renal interstitial fluid angiotensin. Modulation by anesthesia, epinephrine, sodium depletion, and renin inhibition. Hypertension 1995;25:1021-4.[Abstract/Free Full Text]
  • Nishiyama A., Seth DM, Navar LG Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats. Hypertension 2002;39:129-34.[Abstract/Free Full Text]
  • van Kats JP, van Meegen JR, Verdouw PD, Duncker DJ, Schalekamp MA, Danser AH Subcellular localization of angiotensin II in kidney and adrenal. J Hypertens 2001;19:583-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Zou LX, Imig JD, Hymel A., Navar LG Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens 1998;11:570-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • van Kats JP, de Lannoy LM, Jan Danser AH, van Meegen JR, Verdouw PD, Schalekamp MA Angiotensin II type 1 (AT1) receptor-mediated accumulation of angiotensin II in tissues and its intracellular half-life in vivo. Hypertension 1997;30:42-9.[Abstract/Free Full Text]
  • Zou LX, Imig JD, von Thun AM, Hymel A., Ono H., Navar LG Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats. Hypertension 1996;28:669-77.[Abstract/Free Full Text]
  • Ingert C., Grima M., Coquard C., Barthelmebs M., Imbs JL Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats. Am J Physiol Renal Physiol 2002; 283:F1003-F1010.[Abstract/Free Full Text]
  • Hein L., Meinel L., Pratt RE, Dzau VJ, Kobilka BK Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand. Mol Endocrinol 1997;11:1266-77.[Abstract/Free Full Text]
  • Imig JD, Navar GL, Zou LX et al. Renal endosomes contain angiotensin peptides, converting enzyme, and AT(1A) receptors. Am J Physiol 1999;277:F303-F311.[Web of Science][Medline] [Order article via Infotrieve]
  • Linas SL Role of receptor mediated endocytosis in proximal tubule epithelial function. Kidney Int Suppl 1997;61:S18-S21.[CrossRef][Medline] [Order article via Infotrieve]
  • Thekkumkara T., Linas SL Role of internalization in AT(1A) receptor function in proximal tubule epithelium. Am J Physiol Renal Physiol 2002;282:F623-F629.[Abstract/Free Full Text]
  • Romero MF, Hopfer U., Madhun ZT, Zhuo W., Douglas JG Angiotensin actions in the rabbit proximal tubule. Ren Physiol Biochem 2003;14:199-207.
  • Romero MF, Douglas JG, Eckert RL, Hopfer U., Jacobberger JW Development and characterization of rabbit proximal tubular epithelial cell lines. Kidney Int 1992;42:1130-44.[Web of Science][Medline] [Order article via Infotrieve]
  • Chen R., Mukhin YV, Garnovskaya MN et al. A functional angiotensin II receptor-GFP fusion protein: evidence for agonist-dependent nuclear translocation. Am J Physiol Renal Physiol 2000;279:F440-F448.[Abstract/Free Full Text]
  • Pendergrass KD, Averill DB, Ferrario CM, Diz DI, Chappell MC Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2. Lewis rat. Am J Physiol Renal Physiol 2006;290:F1497-F1506.[Abstract/Free Full Text]
  • Morinelli TA, Raymond JR, Baldys A. et al. Identification of a putative nuclear localization sequence within the angiotensin II AT receptor associated with nuclear activation. Am J Physiol Cell Physiol 2007;292:1398-408.[CrossRef]
  • Licea H., Walters MR, Navar LG Renal nuclear angiotensin II receptors in normal and hypertensive rats. Acta Physiol Hung 2002;89:427-38.[CrossRef][Medline] [Order article via Infotrieve]
  • Timmermans PB, Wong PC, Chiu AT et al. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993;45:205-51.[Web of Science][Medline] [Order article via Infotrieve]
  • Zhuo JL, Moeller I., Jenkins T. et al. Mapping tissue angiotensin-converting enzyme and angiotensin AT1, AT2 and AT4 receptors. J Hypertens 1997;16:2027-37.[CrossRef]
  • Ullian ME, Linas SL Role of receptor cycling in the regulation of angiotensin II surface receptor number and angiotensin II uptake in rat vascular smooth muscle cells. J Clin Invest 1989;84:840-6.[Web of Science][Medline] [Order article via Infotrieve]
  • Anderson KM, Peach MJ Receptor binding and internalization of a unique biologically active angiotensin IIcolloidal gold conjugate: morphological analysis of angiotensin II processing in isolated vascular strips. J Vasc Res 1994;31:10-17.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Schelling JR, Linas SL Angiotensin II-dependent proximal tubule sodium transport requires receptor-mediated endocytosis. Am J Physiol 1994;266:C669-C675.[Web of Science][Medline] [Order article via Infotrieve]
  • Schelling JR, Hanson AS, Marzec R., Linas SL Cytoskeleton-dependent endocytosis is required for apical type 1 angiotensin II receptor-mediated phospholipase C activation in cultured rat proximal tubule cells. J Clin Invest 1992;90:2472-80.[Web of Science][Medline] [Order article via Infotrieve]
  • Anborgh PH, Seachrist JL, Dale LB, Ferguson SS Receptor/beta-arrestin complex formation and the differential trafficking and resensitization of beta2-adrenergic and angiotensin II type 1A receptors. Mol Endocrinol 2000; 14:2040-53.[Abstract/Free Full Text]
  • Griendling KK, Delafontaine P., Rittenhouse SE, Gimbrone MA, Jr., Alexander RW Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells. J Biol Chem 1987;262:14555-62.[Abstract/Free Full Text]
  • Sen I., Bull HG, Soffer RL Isolation of an angiotensin IIbinding protein from liver. Proc Natl Acad Sci USA 1984;81:1679-83.[Abstract/Free Full Text]
  • Tang SS, Rogg H., Schumacher R., Dzau VJ Characterization of nucler angiotensin II binding sites in rat liver and comparison with plasma membrane receptors. Endocrinology 1992;131:374-80.[Abstract/Free Full Text]
  • Zhuo JL Intracrine renin and angiotensin II: a novel role in cardiovascular and renal cellular regulation. J Hypertens 2006;24:1017-20.[Web of Science][Medline] [Order article via Infotrieve]
  • Wolf G., Wenzel U., Burns KD, Harris RC, Stahl RA, Thaiss F. Angiotensin II activates nuclear transcription factorkappaB through AT1 and AT2 receptors. Kidney Int 2002; 61:1986-95.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Suzuki Y., Ruiz-Ortega M., Egido J. Angiotensin II: a double-edged sword in inflammation. J Nephrol 2000;13 (suppl 3):S101-S110.[Web of Science][Medline] [Order article via Infotrieve]
  • Kwon TH, Nielsen J., Kim YH, Knepper MA, Frokiaer J., Nielsen S. Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II. Am J Physiol Renal Physiol 2003;285:F152-F165.[Abstract/Free Full Text]
  • Brooks HL, Allred AJ, Beutler KT, Coffman TM, Knepper MA Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice. Hypertension 2002;39:470-3.[Abstract/Free Full Text]
  • Beutler KT, Masilamani S., Turban S. et al. Long-Term Regulation of ENaC Expression in Kidney by Angiotensin II. Hypertension 2003;41:1143-50.[Abstract/Free Full Text]
  • Kurtz TW, Gardner DG Transcription-modulating drugs: a new frontier in the treatment of essential hypertension. Hypertension 1998;32:380-6.[Abstract/Free Full Text]
  • du CD, Chalumeau C., Defontaine N. et al. Angiotensin II stimulates NHE3 activity by exocytic insertion of the transporter: role of PI 3-kinase. Kidney Int 2003;64:939-49.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Moe OW Acute regulation of proximal tubule apical membrane Na?H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors. J Am Soc Nephrol 1999;10:2412-25.[Free Full Text]
  • Turban S., Beutler KT, Morris RG, Masilamani S., Fenton RA, Knepper MA, Packer RK Long-term regulation of proximal tubule acid-base transporter abundance by angiotensin II. Kidney Int 2006;70:660-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Zhuo JL Monocyte chemoattractant protein-1: a key mediator of angiotensin II-induced target organ damage in hypertensive heart disease? J Hypertens 2004;22:451-4.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Duff JL, Berk BC, Corson MA Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells. Biochem Biophys Res Commun 1992;188:257-64.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Marrero MB, Schieffer B., Paxton WG et al. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 1995;375:247-50.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Schmitz U., Ishida T., Ishida M. et al. Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK. Circ Res 1998;82:1272-8.[Abstract/Free Full Text]
  • Molkentin JD, Lu JR, Antos CL et al. A calcineurindependent transcriptional pathway for cardiac hypertrophy. Cell 1998;93:215-28.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Lucchesi PA, Bell JM, Willis LS, Byron KL, Corson MA, Berk BC Ca(2+)-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype. Circ Res 1996;78:962-70.[Abstract/Free Full Text]
  • Mitsuka M., Nagae M., Berk BC Na(+)-H+ exchange inhibitors decrease neointimal formation after rat carotid injury. Effects on smooth muscle cell migration and proliferation. Circ Res 1993;73:269-75.[Abstract/Free Full Text]
  • Jimenez E., Vinson GP, Montiel M. Angiotensin II (AII)-binding sites in nuclei from rat liver: partial characterization of the mechanisms of Ang II accumulation in nuclei. J Endocrinol 1994;143:449-53.[Abstract/Free Full Text]
  • Muller DN, Heissmeyer V., Dechend R. et al. Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage. FASEB J 2001;15:1822-4.[Free Full Text]
  • Mezzano SA, Ruiz-Ortega M., Egido J. Angiotensin II and renal fibrosis. Hypertension 2001;38:635-8.[Abstract/Free Full Text]
  • Hoffmann A., Levchenko A., Scott ML, Baltimore D. The IkappaB-NF-kappaB signalling module: temporal control and selective gene activation. Science 2002;298:1241-5.[Abstract/Free Full Text]
  • Stancovski I., Baltimore D. NF-kappaB activation: the I kappaB kinase revealed? Cell 1997;91:299-302.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ruiz-Ortega M., Lorenzo O., Ruperez M., Blanco J., Egido J. Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors. Am J Pathol 2001;158:1743-56.[Abstract/Free Full Text]
  • Zhuo JL, Carretero OA, Li XC Effects of AT1a receptor-mediated endocytosis of extracellular angiotensin II on activation of nuclear factor-KB in proximal tubule cells. Ann NY Acad Sci 2006;1091:336-45.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Journal of Renin-Angiotensin-Aldosterone System, Vol. 8, No. 1, 23-33 (2007)
DOI: 10.3317/jraas.2007.003
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
T. M. Gwathmey, H. A. Shaltout, K. D. Pendergrass, N. T. Pirro, J. P. Figueroa, J. C. Rose, D. I. Diz, and M. C. Chappell
Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production
Am J Physiol Renal Physiol, June 1, 2009; 296(6): F1484 - F1493.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. E. Hoch, T. J. Guzik, W. Chen, T. Deans, S. A. Maalouf, P. Gratze, C. Weyand, and D. G. Harrison
Regulation of T-cell function by endogenously produced angiotensin II
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R208 - R216.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
X. C. Li and J. L. Zhuo
Intracellular ANG II directly induces in vitro transcription of TGF-{beta}1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors
Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1034 - C1045.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Zhuo, J. L
Right arrow Articles by Li, X. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhuo, J. L
Right arrow Articles by Li, X. C
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Advertisement