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Renin Academy in Focus
AH Jan Danser
Department of Internal Medicine, room E1418b, Erasmus MC, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
References
- Danser AHJ, Derkx FHM, Schalekamp Madh, Hense HW, Riegger GAJ, Schunkert H. Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans. J Hypertens 1998;16:853-862.[CrossRef][Web of Science][Medline]
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- Saris JJ, Derkx FHM, de Bruin RJA et al. High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin. Am J Physiol 2001;280:H1706-H1715.[Web of Science]
- Batenburg WW, Krop M., Garrelds IM et al. Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens 2007;25:2441-53.[Web of Science][Medline]
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- Huang Y., Wongamorntham S., Kasting J. et al. Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin IIindependent mechanisms. Kidney Int 2006;69:105-13.[CrossRef][Web of Science][Medline]
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- Saris JJ, 't Hoen PAC, Garrelds IM et al. Prorenin induces intracellular signalling in cardiomyocytes independently of angiotensin II. Hypertension 2006;48:564-71.[Abstract/Free Full Text]
- Ludwig J., Kerscher S., Brandt U. et al. Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. J Biol Chem 1998;273:10939-47.[Abstract/Free Full Text]
- Danser AHJ, Deinum J. Renin, prorenin and the putative (pro)renin receptor. Hypertension 2005:1069-76.
- Re RN, Cook JL Mechanisms of disease: Intracrine physiology in the cardiovascular system. Nat Clin Pract Cardiovasc Med 2007;4:549-57.[CrossRef][Web of Science][Medline]
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Journal of Renin-Angiotensin-Aldosterone System, Vol. 8, No. 4,
212 (2007)
DOI: 10.3317/jraas.2007.033

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