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Experimental models for nephropathy

ISF College of Pharmacy, Moga, India, pbala2006{at}gmail.com

Vishal Arvind Chakkarwar

ISF College of Pharmacy, Moga, India

Vijay Kumar

Department of Pharmacy, Lovely Professional University, Jalandhar, India

Akash Jain

ISF College of Pharmacy, Moga, India

Jayarami Reddy

ISF College of Pharmacy, Moga, India

Manjeet Singh

ISF College of Pharmacy, Moga, India

Nephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialised nations. Nephropathy is characterised to varying degrees by nodular glomerulosclerosis, glomerular basement membrane thickness and mesangial expansion, leading to a decline in glomerular filtration rate, persistent elevated albuminuria, elevated arterial blood pressure and fluid retention. Hyperglycaemia, hyperlipidaemia and hypertension are considered to be the major risk factors implicated in the progression of nephropathy.Various signalling systems, such as vasoconstrictor peptides, inflammatory mediators, growth factors and adhesion molecules, are involved in the pathogenesis of nephropathy.At present, no promising therapy is available to treat patients with nephropathy due to lack of understanding of signalling culprits involved in the pathogenesis of nephropathy. Animal models are being developed to better understand the disease pathogenesis and develop drugs for nephropathy. In the present review, we have discussed various animal models for nephropathy, which may open vistas for developing new drugs to treat nephropathy.

Key Words: animal models • nephropathy • signalling mechanisms

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 9, No. 4, 189-195 (2008)
DOI: 10.1177/1470320308098343


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Balakumar, P. Articles by Singh, M. Search for Related Content PubMed PubMed Citation Articles by Balakumar, P. Articles by Singh, M. Pubmed/NCBI databases Medline Plus Health Information Kidney Diseases Social Bookmarking                         What's this?