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Renin-angiotensin system-related highlights from the High Blood Pressure Research Conference annual meeting
Friedrich C Luft
Experimental and Clinical Research Center, Berlin, Germany
The High Blood Pressure Research Conference of the American Heart Association is a theoretical meeting for hypertension researchers who direct their attention to hypertension-related basic disease mechanisms. The items that I have selected for this brief review are molecular intracellular receptor function, novel angiotensin (Ang)-related pathways, including Ang-(1-7), the Mas receptor, and angiotensin-converting enzyme 2, oxidative stress, immunity, the (pro)renin receptor, and until now unappreciated signalling pathways, such as the tonicity element binding protein.
References
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- Feldt S., Maschke U., Dechend R., Luft FC, Muller DN The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. J Am Soc Nephrol 2008;19:743-8.[Abstract/Free Full Text]
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- Miyakawa H., Woo SK, Dahl SC, Handler JS, Kwon HM Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci U S A 1999;96:2538-42.[Abstract/Free Full Text]
Journal of Renin-Angiotensin-Aldosterone System, Vol. 9, No. 4,
242-247 (2008)
DOI: 10.1177/1470320308100546

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